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In the brain, nicotine works mostly to release other neurotransmitterslike dopamine (pleasure), norepinephrine (arousal and appetite suppression), glutamate (learning and memory), endogenous opiates, and serotonin (mood modulation)

If you have other heart disease risk factors such as unhealthy blood cholesterol levels, high blood pressure, and overweight or obesity, smoking raises your risk of heart disease even more

The CDC links smoking to an increased risk of cancer, heart disease and lung disease

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